Scientist III

Overview

Develop and scale downstream purification processes for biologic drug candidates

Key Responsibilities

• record keeping
• scale-up
• inventory management
• downstream development
• instrument maintenance
• data review

Tasks

-Maintain complete and accurate records of laboratory work in conformance with standard operating procedures (SOPs) and training. -Undertake production campaigns from Lab to Pilot Scale. -Maintain the inventory of laboratory consumables and clean glassware. -Develop and execute laboratory studies in downstream process development to support unit operation scale-up and technology transfers. -Establish, maintain, and lead internal downstream process development and scale-up lab capabilities in CMC Biologics. -Collaborate with internal and external partners in upstream process development, analytical development, and formulation development groups. -Coordinate vendor service calls for repair and maintenance of laboratory instruments, perform routine maintenance of laboratory instrumentation, and maintain complete and accurate records of instrument service and repairs. -Provide detailed reviews of peer-generated data as well as that generated from contracted service providers.

Requirements

• master’s
• bachelor’s
• chromatography
• viral filtration
• fplc
• gmp

What You Bring

-Master’s degree in chemistry, biochemistry, biochemical engineering, chemical engineering or related field with a minimum of one year of relevant drug discovery/development experience. -Experience developing scalable chromatography purification unit operations. -Ability to run basic analytical purity assays and in-process impurity clearance assays independently. -Demonstrated capability to work independently on complex technical problems and effectively in cross-functional teams. -Bachelor’s degree in chemistry, biochemistry, biochemical engineering, chemical engineering or related field with a minimum of three years of relevant drug discovery/development experience. -Experience developing scalable viral filtration and TFF unit operations. -Experience with Fast Protein Liquid Chromatography (FPLC) systems for chromatography-based purification development. -Working knowledge of CMC upstream process development, analytical development, formulation development, bioconjugation process development, technology transfer, and GMP quality requirements. -Hands-on experience in recombinant protein purification and downstream process development. -Familiarity with harvest and clarification unit operations.

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Benefits

-Employee Assistance Program -Life Insurance (Voluntary Life & AD&D for the employee and dependents) -Health Spending Account (HSA) -Transportation benefits -Critical Illness, Accident, and Hospital -Medical, dental & vision -Time Off/Leave (PTO, Vacation or Sick Leave) -Short and long-term disability -401(k) Retirement Plan – Pre-tax and Roth post-tax contributions available

About Actalent

-Born in July 2021 by merging Aerotek’s engineering & sciences arm with EASi, Actalent emerged as a focused engineering-and-science partner. -Backed by Allegis Group, it drives scale and speed to market via contract, managed, and technical services. -Headquartered in Maryland with global reach, it deploys specialized teams across North America, Europe, and APAC on Fortune 500 projects. -Typical engagements span EV design, vaccine development, lab services, clinical research, and infrastructure systems. -Expertise covers a wide spectrum: aerospace, defense, healthcare, manufacturing, software systems, environmental and civil engineering.

Sector Specialisms