Scientist II

Overview

Develop and execute LC/MS bioanalysis for biologics PK/PD studies.

Key Responsibilities

• lc/ms operation
• data analysis
• assay development
• affinity purification
• assay optimization
• data communication

Tasks

-Communicate data interpretation internally and externally. -Operate and maintain LC/MS instruments to generate high-quality experimental data. -Analyze data and maintain detailed, accurate and comprehensive study documentation in electronic laboratory notebooks. -Perform affinity purification of therapeutic proteins (including but not limited to monoclonal and bispecific antibodies, antibody drug conjugates, antibody-siRNA conjugates, and fusion proteins) from biological matrices. -The main function of this position is to develop and implement LC/MS (liquid chromatography/mass spectrometry)-based bioanalysis and in vitro characterization assays for novel biologics entities. -Facilitate assay optimization and implementation to ensure laboratory capacity and data quality.

Requirements

• lc/ms
• mass spectrometry
• qqq
• qtof
• liquid handling
• chemistry

What You Bring

-Prior industry experience in drug discovery/development is preferred. In-depth understanding of PK, TK and PK/PD studies and corresponding bioanalytical assays as well as in vitro characterization assays is highly desired. -Experience on routine LC/MS-based bioanalysis to support in vivo PK, TK, and PK/PD studies -Highly motivated, self-driven and results-oriented with excellent communication and presentation skills; capable of working both as a team player and individual contributor. -Hands-on experience with automated liquid handling systems is highly desired. -Hands-on experience with oligonucleotide analysis is highly desired. -Hands-on experience with QQQ (SCIEX), qTOF (Agilent, Bruker, SCIEX) and/or Orbitrap (Thermo) mass spectrometers is highly desired. -Degree in chemistry, pharmacology or other related fields. BS with 5+ years or MS with 2+ years in a pharmaceutical industry setting with a focus on mass spectrometry.

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About Orion Group

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