Scientist III

Overview

Protein characterization using MS, LC, CE, and biophysical assays in pharma.

Key Responsibilities

• hplc separation
• lc‑ms analysis
• dsc
• spectroscopy
• data generation
• equipment maintenance

Tasks

-Draft protocols, method development reports, and technical characterization reports. -Maintain lab equipment. -Generate and communicate precise, reliable, and reproducible data in a timely manner. -Independently perform separation methods (e.g., fractionation & analysis of variants) using HPLC and AKTA -Support process development by performing raw material analysis using vibrational spectroscopy and executing metabolomics experiments using mass spectrometry. -Perform mass spectrometry analyses (i.e., intact/reduced mass analysis by LC-MS and peptide mapping by LC-MS) of biologics to provide sequence verification and post-translational modification profiles. -Design and execute experiments for method development and/or investigations. -Perform biophysical methods (e.g., DSC) of biologics to support characterization studies. -Organize and document experiments and results in an electronic laboratory notebook.

Requirements

• hplc
• mass spectrometry
• spectroscopy
• bioinformatics
• microsoft office
• bsc/msc

What You Bring

-Knowledge of HPLC or AKTA instrumentation -Working knowledge of bioinformatics tools to process and analyze mass spectrometry data is highly desirable. -Knowledge of vibrational spectroscopy (e.g., IR, NIR and Raman) and multivariate analysis is desirable. -Excellent written communication, oral communication, organization, and multitasking skills. -Hands-on experience with protein mass spectrometry, liquid chromatography, capillary electrophoresis and protein biophysical characterization. -Proficient with Windows 10 and Microsoft Office (Outlook, Excel, Word, and PowerPoint). -Bachelors or Masters in chemistry, biology, biochemistry or related technical discipline with typically 5+ (BS) or 2+ (MS) years of relevant experience in biotech/pharmaceutical industry setting. -Fundamental understanding of protein structure, post-translational modifications, and analytical methods used for protein characterization.

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About Orion Group

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Sector Specialisms