Principal Research Scientist VI

Description

• Ensure proper documentation of all experiments and data.
• Troubleshoot highly complex tasks through independent and team-based efforts.
• Share knowledge and expertise to expand team capabilities and promote collaboration.
• Serve as the DMPK project representative for global, cross-functional small molecule project teams to achieve project goals.
• Write and review collaborative research manuscripts, project documents, and milestone reports.
• Make independent decisions related to day-to-day experimental activities.
• Represent the organization at scientific conferences and global meetings.
• Actively participate in cross-functional teams and meetings to drive project success.
• Analyze complex data, connect disparate datasets to reach conclusions, and communicate project updates and experimental results to stakeholders.
• Work closely with CROs to oversee DMPK experimental design, implementation, and interpretation.
• Provide expert-level guidance on experimental plans and data interpretation with strong expertise in either ADME/PK/DDI or PK/PD modeling and simulation.

Requirements

• Publications, abstracts, or posters demonstrating expertise in metabolism, drug interaction, or PK/PD modeling.
• Ability to distinguish isolated risks vs. project-level risks.
• Experience correlating in vitro potency with in vivo outcomes.
• Bachelor’s with 18+ years relevant experience.
• Master’s with 12+ years OR
• PhD with ~6–10+ years project-facing experience OR
• Demonstrate deep subject matter expertise and creative, independent thinking to address critical scientific questions.
• Strong communicator, collaborative, proactive problem-solver.
• Comfortable interacting with chemists, pharmacologists, and cross-functional colleagues.
• Absorption, ADME, PK/PD, metabolism, drug interaction, project management, GMP.
• Deep understanding of absorption, distribution, metabolism, excretion principles.
• Minimum 3+ years actively participating on discovery project teams (hit-to-lead, lead optimization).
• Ability to evaluate drug-drug interaction risks, clearance pathways, and biotransformation.

Benefits

• Employee Assistance Program
• Time Off/Leave (PTO, Vacation or Sick Leave) Workplace Type This is a fully onsite position in Lexington,MA. Application Deadline This position is anticipated to close on Dec 22, 2025.
• Medical, dental & vision
• Transportation benefits
• Health Spending Account (HSA)
• Short and long-term disability
• 401(k) Retirement Plan – Pre-tax and Roth post-tax contributions available
• Critical Illness, Accident, and Hospital
• Life Insurance (Voluntary Life & AD&D for the employee and dependents)

Training + Development

Interview process

Visa Sponsorship

Security clearance