Principal Research Scientist VI

Description

• Actively participate in cross-functional meetings and contribute to project strategy.
• Troubleshoot complex scientific challenges independently and collaboratively.
• Serve as the DMPK representative on global, cross-functional small molecule project teams to achieve project milestones.
• Analyze and integrate complex datasets to drive informed decisions and communicate results to stakeholders.
• Provide expert guidance on experimental plans and data interpretation, with deep expertise in ADME/PK/DDI or PK/PD modeling and simulation.
• Ensure accurate documentation of all experiments and data.
• Share knowledge and mentor team members to expand organizational capabilities.
• Design, implement, and interpret DMPK studies in partnership with CROs.
• Represent the organization at scientific conferences and global meetings through presentations and publications.

Requirements

• Ability to manage multiple priorities and solve complex problems proactively.
• Master’s degree with 12+ years OR Bachelor’s degree with 18+ years relevant experience.
• Excellent communication and collaboration skills.
• Minimum 3+ years actively contributing to discovery project teams (hit-to-lead, lead optimization).
• Proven expertise in metabolism, biotransformation, or PK/PD modeling (depth in at least one area).
• Ph.D. with ~6–10+ years of project-facing experience OR
• Strong understanding of ADME principles, drug-drug interaction risks, clearance pathways, and biotransformation.
• Demonstrated thought leadership through publications, abstracts, or posters.
• Ability to correlate in vitro potency with in vivo outcomes.
• Comfortable interacting with chemists, pharmacologists, and cross-functional colleagues.

Benefits

• Employee Assistance Program
• Medical, dental & vision
• Transportation benefits
• Health Spending Account (HSA)
• Short and long-term disability
• 401(k) Retirement Plan – Pre-tax and Roth post-tax contributions available
• Critical Illness, Accident, and Hospital
• Time Off/Leave (PTO, Vacation or Sick Leave) Workplace Type This is a fully onsite position in Lexington,MA. Application Deadline This position is anticipated to close on Dec 25, 2025.
• Life Insurance (Voluntary Life & AD&D for the employee and dependents)

Training + Development

Interview process

Visa Sponsorship

Security clearance